Journal of Medicinal Chemistry p. 4557 - 4569 (1995)
Update date:2022-08-06
Topics: Inhibitors Bioassay High-Throughput Screening Pharmacokinetics Enzyme Kinetics Assay
Patel, Dinesh V.
Rielly-Gauvin, Katherine
Ryono, Denis E.
Free, Charles A.
Rogers, W. Lynn
et al.
The design and application of α-hydroxy phosphonates, a new class of transition state analogs, toward the discovery of novel and potent inhibitors of the aspartyl protease renin is described.Tripeptidic α-hydroxy diethyl phosphonate 3, the first example i
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