Probing binding preferences of DNA and RNA: Backbone chirality of thioacetamido-linked nucleic acids and iso-thioacetamido-linked nucleic acids to differentiate DNA versus RNA selective binding

Article abstract of DOI:10.1021/jo1014036

Subtle differences in RNA and DNA duplex geometry could be sensed by the changed stereochemistry at 3′-amino function in the 5-atom thioacetamido linker of thioacetamido-linked nucleic acids and iso-thioacetamido-linked nucleic acids modified oligomers. I