Evaluation of some Mannich bases of conjugated styryl ketones and related compounds versus the WiDr colon cancer in vitro

DOI: 10.1016/0223-5234(89)90002-0

Source and publish data:

European Journal of Medicinal Chemistry p. 217 - 226 (1989)

Update date:2022-08-03

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Authors:

Dimmock, Jonathan R.

Phillips, Oludotun A.

Wonko, Sheri L.

Hickie, Robert A.

Tuer, Robert G.

et al et al

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Article abstract of DOI:10.1016/0223-5234(89)90002-0

The series of Mannich bases and one group of related α-aminoketones which had either 1 or 2 sites for thiol alkylation were evaluated againts the WiDr tumour in vitro.Maximum activity was found in the bis alkylating agents (12-64 times the activity of the

Full text of DOI:10.1016/0223-5234(89)90002-0

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