Inhibition of 5-lipoxygenase by substituted 3,4-dihydro-2H-1,4-thiazines

DOI: 10.1002/jps.2600781112

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Journal of Pharmaceutical Sciences p. 937 - 943 (1989)

Update date:2022-08-04

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Authors:

Weintraub

Skoog Skoog

Nichols Nichols

Wiseman Wiseman

Huber Huber

Baugh Baugh

Farrell Farrell

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Article abstract of DOI:10.1002/jps.2600781112

A series of substituted 3,4-dihydro-2H-1,4-thiazines inhibit 5-lipoxygenase from rat leukocytes and exhibit submicromolar IC₅₀ values. A novel synthesis of these compounds was developed based on the formation of hydroxymethyleneamine 13 and its

Full text of DOI:10.1002/jps.2600781112

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