Studies on Hindered Phenols and Analogues. 2. 1,3-Benzoxathioles Having SRS-A Inhibiting Activity

DOI: 10.1021/jm00167a032

Source and publish data:

Journal of Medicinal Chemistry p. 1491 - 1496 (1990)

Update date:2022-08-04

Topics: Synthesis IC50 HPLC (high-performance liquid chromatography) Analogues Biological Evaluation Structure-Activity Relationship (SAR) Anti-Inflammatory Spectroscopic Analysis In vitro assay Inhibiting activity Hindered phenols

Authors:

Aizawa, Yuichi

Kanai, Tsutomu

Hasegawa, Kazuo

Yamaguchi, Takeshi

Iizuka, Yoshio

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00167a032

A series of hindered phenolic 1,3-benzoxathioles (7a-1) were prepared and investigated for biological properties.Many compounds had LPO-lowering, antisuperoxide inhibiting, SRS-A inhibiting, and 5-lipoxygenase inhibiting activities.Among them, 5-hydroxy-4

Full text of DOI:10.1021/jm00167a032

Products guided by the article

Product name:3,3',5,5',6,6'-hexamethyl-2,2'-trithiobishydroquinone

Cas No:125714-64-9

R&D Labs maybe for 125714-64-9

Hubei Sibo Technology Co.,Ltd.

Contact:0715-6597222

Address:Pan Jia Wan fan Lake Chemical Industrial Park ,Xianning City, Hubei, China
Ningbo J&S Botanics Inc.

Contact:86-574-26865651

Address:529 YuanBaoShan Road, Beilun District
WUXI HONOR SHINE CHEMICAL CO.,LTD

Contact:+86-510-83593312

Address:No.1699 Huishan avenue,Huishan district,Wuxi ,Jiangsu,China,214177.(Wuxi Huishan Ecomonic Develop Zone )
DU-HOPE INTERNATIONAL GROUP

Contact:+86-25-52346955

Address:199,JIANYE ROAD,NANJING,CHINA
Hubei Xinghuo Chemical Co., Ltd.,

Contact:13925817279 13907299441

Address:Xinghuo Fine Chemistry Industrial Park, Xiaochang County, Hubei Province, China

Relevant to this article

Effect on carbon lengthening at the side chain terminal of 1α,25-dihydroxyvitamin D₃ for calcium regulating activity

Doi:10.1248/cpb.38.1246
(1990)
Synthesis and antiplasmodial activity of highly active reverse analogues of the antimalarial drug candidate fosmidomycin

Doi:10.1002/cmdc.201000276
(2010)
Hydroxyalkylation of [60]fullerene: Free radical addition of alcohols to C₆₀

Doi:10.1039/c0cc02836c
(2010)
Asymmetric Isothiourea-Catalysed Formal [3+2] Cycloadditions of Ammonium Enolates with Oxaziridines

Doi:10.1002/chem.201501271
(2015)
Rhodium-catalysed intermolecular alkyne hydroacylation: The enantioselective synthesis of α- and β-substituted ketones by kinetic resolution

Doi:10.1002/chem.201001748
(2010)
Synthesis and pharmacological evaluation of some 4-Oxo-quinoline-2- carboxylic acid derivatives as anti-inflammatory and analgesic agents

Doi:10.1002/ardp.201000016
(2010)

Article Doi