Studies on Hindered Phenols and Analogues. 2. 1,3-Benzoxathioles Having SRS-A Inhibiting Activity

DOI: 10.1021/jm00167a032

Source and publish data:

Journal of Medicinal Chemistry p. 1491 - 1496 (1990)

Update date:2022-08-04

Topics: Synthesis IC50 HPLC (high-performance liquid chromatography) Analogues Biological Evaluation Structure-Activity Relationship (SAR) Anti-Inflammatory Spectroscopic Analysis In vitro assay Inhibiting activity Hindered phenols

Authors:

Aizawa, Yuichi

Kanai, Tsutomu

Hasegawa, Kazuo

Yamaguchi, Takeshi

Iizuka, Yoshio

et al. et al.

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Article abstract of DOI:10.1021/jm00167a032

A series of hindered phenolic 1,3-benzoxathioles (7a-1) were prepared and investigated for biological properties.Many compounds had LPO-lowering, antisuperoxide inhibiting, SRS-A inhibiting, and 5-lipoxygenase inhibiting activities.Among them, 5-hydroxy-4

Full text of DOI:10.1021/jm00167a032

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