Helvetica Chimica Acta p. 2086 - 2093 (2010)
Update date:2022-09-26
Topics:
Kobayashi, Kazuhiro
Kozuki, Taketoshi
Fukamachi, Shuhei
Konishi, Hisatoshi
A convenient method for the synthesis of 2,4,8-trisubstituted 1,7-naphthyridines 6 by the reaction of (E)-4-(1-aryl-2-methoxyethenyl)-3- isocyanopyridines 4, which could be easily prepared from commercially available 3-aminopyridine via aroylation of lithium (4-lithiopyridin-3-yl)pivalamide with N-methoxy-N-methylbenzamides, with excess organolithiums has been developed.
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