USE OF AN ALLYLIC ANCHOR GROUP AND OF ITS PALLADIUM CATALYZED HYDROSTANNOLYTIC CLEAVAGE IN THE SOLID PHASE SYNTHESIS OF PROTECTED PEPTIDE FRAGMENTS

Article abstract of DOI:10.1016/S0040-4039(00)99087-7

The allylic handle -O-CH2-CH=CH-CH2-O-CH2-CO- has been used in the synthesis of protected peptide fragments on aminomethyl polystyrene.The palladium-catalyzed hydrostannolytic cleavage of the peptide fragments from the resin occurs under very mild conditions.