Studies on neurokinin antagonists. 1. The design of novel tripeptides possessing the glutaminyl-D-tryptophylphenylalanine sequence as substance P antagonists

DOI: 10.1021/jm00089a011

Source and publish data:

Journal of Medicinal Chemistry p. 2015 - 2025 (1992)

Update date:2022-08-05

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Authors:

Hagiwara

Miyake Miyake

Morimoto

Murai Murai

Fujii Fujii

Matsuo Matsuo

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Article abstract of DOI:10.1021/jm00089a011

To discover a novel and low molecular weight substance P (SP) antagonist we postulated that the essential binding domain of peptide ligands was only a small portion in the whole structure. On the basis of this assumption, we selected the known octapeptide

Full text of DOI:10.1021/jm00089a011

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