3-O-Alkylascorbic Acids as Free Radical Quenchers. 3. Protective Effect on Coronary Occlusion-Reperfusion Induced Arrhythmias in Anesthetized Rats

Article abstract of DOI:10.1021/jm00087a017

Structural modification of ascorbic acid by substitution of the 3-hydroxy group with lipophilic moieties has allowed the development of agents for treating reperfusion injury.These ascorbic acid derivatives inhibited lipid peroxidation, and some of them also reduced coronary reperfusion-induced arrhythmias in anesthetized rats.We found that 3-O-<(dodecylcarbonyl)methyl>ascorbic acid (8) was protective against reperfusion injury without directly influencing hemodynamics. 2-O-Octadecylascorbic acid (19) and 5,6-O-dodecylideneascorbic acid (15) also exhibited a marked effect on reperfusion injury, but significantly reduced the arterial blood pressure and heart rate in rats.