Journal of Medicinal Chemistry p. 1618 - 1623 (1992)
Update date:2022-09-26
Topics:
Nihro, Yasunori
Sogawa, Satoshi
Izumi, Akihiro
Sasamori, Akihiro
Sudo, Tadamitsu
et al.
Structural modification of ascorbic acid by substitution of the 3-hydroxy group with lipophilic moieties has allowed the development of agents for treating reperfusion injury.These ascorbic acid derivatives inhibited lipid peroxidation, and some of them also reduced coronary reperfusion-induced arrhythmias in anesthetized rats.We found that 3-O-<(dodecylcarbonyl)methyl>ascorbic acid (8) was protective against reperfusion injury without directly influencing hemodynamics. 2-O-Octadecylascorbic acid (19) and 5,6-O-dodecylideneascorbic acid (15) also exhibited a marked effect on reperfusion injury, but significantly reduced the arterial blood pressure and heart rate in rats.
View MoreMelone Pharmaceutical Co., ltd
Contact:+86-411 82593920, 82593631
Address:No 232, JInma Roda, Development Zone, Dalian, China
Anhui Gusheng Import&Export CO.,LTD
Contact:86-551-63662296
Address:Jinzhai Road NO.162 ,hefei, china
Jiangxi Hito Chemical Co., Ltd.
Contact:+86-792-3170318
Address:No. 6, Tianhong Ave., Xinghuo Industry Park, Yongxiu, Jiujiang, Jiangxi, China
Hangzhou Zhenghan Biological Technology Co., Ltd.
Contact:86-571-88781753
Address:liangzhu yuhang hangzhou city
Contact:+86-10-83993285
Address:Rm.1708, Haobai Tower, Building 6, No.50, North Road, West Third Ring, Haidian District, Beijing, China
Doi:10.1007/BF00960350
()Doi:10.1016/S0040-4020(01)85436-3
(1990)Doi:10.1142/S1088424610002938
(2010)Doi:10.1002/chem.201900951
(2019)Doi:10.1021/ol2005159
(2011)Doi:10.1248/cpb.44.515
(1996)
