Facile synthesis of (-)-6-acetoxy-5-hexadecanolide by organocatalytic -oxygenation-allylation-RCM strategy

Article abstract of DOI:10.1055/s-0030-1258248

An asymmetric total synthesis of (-)-6-acetoxy-5-hexadecanolide has been accomplished by employing a seven-step sequence. Asymmetric α- benzoyloxylation of dodecanal followed by indium-mediated one-pot allylation produces the anti-1,2-diol. The six-membered lactone ring is constructed by RCM reaction.