Tetrahedron p. 4627 - 4636 (1989)
Update date:2022-08-04
Topics:
Mooiweer, Hendrik H.
Hiemstra, Henk
Speckamp, W. Nico
The synthesis of a series of χ,δ-unsaturated N-protected α-amino acid methylesters from the coupling of different allylsilanes and glycidyl cation equivalents 6 and 7 is described.Reactions with methoxyglycine derivative 6 are induced with BF3*OEt2; in the case of chloroglycine derivative 7 SnCl4 is used as Lewis acid.Reactions are fully regioselective, but show low stereoselectivity.The conversion of the reaction products into unprotected α-amino acids is described for two cases.
View MoreContact:+852 83038667
Address:Room 1502, 15th Floor, SPA Centre,53-55 Lockhart Road, Wanchai, Hong Kong
Nanjing Vincero International Trading Co.,Ltd
Contact:8618936897229
Address:NO.68, ZhuShan Road, JiangNing WanDa Plaza, Building E Room 1703
Contact:86-379-63338609
Address:Jiudian Village,Deting Town,Song County,Luoyang
Suzhou Chiral Pharmaceuticals Co., Ltd.
Contact:86-0512-63197058
Address:Building A, No. 2358, Chang'an Road, Wujiang Science Park
Fujian Wanke Pharmaceutical Co., LTD.
Contact:+86-598-5026002
Address:Economic development zone,jiangle county
Doi:10.1039/c5dt01322d
(2015)Doi:10.1016/j.bmcl.2013.09.021
(2013)Doi:10.3762/bjoc.14.100
(2018)Doi:10.1016/0022-328X(89)85097-1
(1989)Doi:10.1039/c0ob00518e
(2011)Doi:10.1016/j.bmcl.2010.11.064
(2011)
