Stereoselective total syntheses of the antitumor antibiotics (+)-actinobolin and (-)-bactobolin from a common bridged lactone intermediate

Article abstract of DOI:10.1021/ja00165a035

Efficient, highly steroselective approaches have been developed to (+)-actinobolin (1) and (-)-bactobolin (3) from bridged α-keto lactone 11, which can be readily prepared via intramolecular SnCl₄ catalyzed ene reaction of cyclohexenol glyoxyla