Modulation of PPAR subtype selectivity. Part 2: Transforming PPARα/γ dual agonist into α selective PPAR agonist through bioisosteric modification

DOI: 10.1016/j.bmcl.2010.12.032

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 628 - 632 (2011)

Update date:2022-08-04

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Authors:

Zaware, Pandurang

Shah, Shailesh R.

Pingali, Harikishore

Makadia, Pankaj

Thube, Baban

Pola, Suresh

Patel, Darshit

Priyadarshini, Priyanka

Suthar, Dinesh

Shah, Maanan

Jamili, Jeevankumar

Sairam, Kalapatapu V.V.M.

Giri, Suresh

Patel, Lala

Patel, Harilal

Sudani, Hareshkumar

Patel, Hiren

Jain, Mukul

Patel, Pankaj

Bahekar, Rajesh

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Article abstract of DOI:10.1016/j.bmcl.2010.12.032

A novel series of oxime containing benzyl-1,3-dioxane-r-2-carboxylic acid derivatives (6a-k) were designed as selective PPARα agonists, through bioisosteric modification in the lipophilic tail region of PPARα/γ dual agonist. Some of the test compounds (6a

Full text of DOI:10.1016/j.bmcl.2010.12.032

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