Spiro hydantoin aldose reductase inhibitors derived from 8-aza-4-chromanones

DOI: 10.1021/jm00169a005

Source and publish data:

Journal of Medicinal Chemistry p. 1859 - 1865 (1990)

Update date:2022-08-05

Topics:

Authors:

Sarges Sarges

Goldstein

Welch Welch

Swindell

Siegel Siegel

Beyer Beyer

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Article abstract of DOI:10.1021/jm00169a005

A series of spiro hydantoins derived from 8-azachromanones (2,3-dihydro-4H-pyrano[2,3-b]pyridin-4-ones) has been prepared and tested for aldose reductase inhibitory activity. The standard Bucherer-Bergs conditions had to be drastically modified to increas

Full text of DOI:10.1021/jm00169a005

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Product name:(2R,4S)-6-Chloro-2-methyl-4-ureido-3,4-dihydro-2H-pyrano[2,3-b]pyridine-4-carboxylic acid; compound with benzyl-((S)-1-phenyl-ethyl)-amine

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