Bioorganic and Medicinal Chemistry Letters p. 484 - 487 (2011)
Update date:2022-07-30
Topics:
Boyd, Michael J.
Berthelette, Carl
Chiasson, Jean-Franois
Clark, Patsy
Colucci, John
Denis, Danielle
Han, Yongxin
Lévesque, Jean-Francois
Mathieu, Marie-Claude
Stocco, Rino
Therien, Alex
Rowland, Steve
Wrona, Mark
Xu, Daigen
A novel series of EP4 ligands, based on a benzyl indoline scaffold, has been discovered. It was found that agonism and antagonism in this series can be easily modulated by minor modifications on the benzyl group. The pharmacokinetic, metabolic
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