Synthesis and pharmacologic study of pyridazino[4,5-b]carbazoles

DOI: 10.1248/cpb.37.2679

Source and publish data:

Chemical and pharmaceutical bulletin p. 2679 - 2682 (1989)

Update date:2022-09-26

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Authors:

Landelle

Laduree Laduree

Cugnon de Sevricourt

Robba Robba

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Article abstract of DOI:10.1248/cpb.37.2679

Cyclization reaction of hydrazine with carbazole-2,3-methyl dicarboxylates gave 1,4-dioxo-1,2,3,4-tetrahydropyridazino[4,5-b]carbazoles. Chlorodehydroxylation provided 1,4-dichloropyridazino[4,5-b]carbazoles and nucleophilic substitution gave 1,4-dialkoxy pyridazino[4,5-b]carbazoles. These compounds were tested for cytotoxic activity against L1210 leukemia in mice.

Full text of DOI:10.1248/cpb.37.2679

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