Marine Drugs p. 1307 - 1320 (2012)
Update date:2022-07-30
Topics:
Lu, Xi-Lin
Xu, Zhong-Liang
Yao, Xiao-Li
Su, Feng-Juan
Ye, Cheng-Hui
Li, Jing
Lin, Yong-Cheng
Wang, Guang-Lei
Zeng, Jin-Sheng
Huang, Ru-Xun
Ou, Jing-Song
Sun, Hong-Shuo
Wang, Li-Ping
Pang, Ji-Yan
Pei, Zhong
Cyclotripeptide X-13 is a core of novel marine compound xyloallenoide A isolated from mangrove fungus Xylaria sp. (no. 2508). We found that X-13 dose-dependently induced angiogenesis in zebrafish embryos and in human endothelial cells, which was accompanied by increased phosphorylation of eNOS and Akt and NO release. Inhibition of PI3K/Akt/eNOS by LY294002 or L-NAME suppressed X-13-induced angiogenesis. The present work demonstrates that X-13 promotes angiogenesis via PI3K/Akt/eNOS pathways.
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