Effect of structure on potency and selectivity in 2,6-disubstituted 4-(2-arylethenyl)phenol lipoxygenase inhibitors

DOI: 10.1021/jm00169a010

Source and publish data:

Journal of Medicinal Chemistry p. 1892 - 1898 (1990)

Update date:2022-08-03

Topics:

Authors:

Lazer Lazer

Wong Wong

Wegner Wegner

Graham Graham

Farina Farina

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Article abstract of DOI:10.1021/jm00169a010

A series of 2,6-disubstituted 4-(2-arylethenyl)phenols with potent human neutrophil 5-lipoxygenase (5-LO) inhibiting activity (IC₅₀s in the 10^-7 M range) and weaker human platelet cyclooxygenase (CO) inhibiting activity (IC_{50
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Full text of DOI:10.1021/jm00169a010

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