Bioorganic and Medicinal Chemistry Letters p. 1057 - 1059 (2011)
Update date:2022-09-26
Topics:
Wang, Hongliang
Xiao, Junhai
Gao, Dapeng
Zhang, Xian
Yan, Hui
Gong, Zehui
Sun, Tinmin
Li, Song
A series of chloro-pyridazine piperazines were developed based on the structure of human rhinovirus (HRV) capsid-binding inhibitors with proven activity using a pharmacophore model. A preliminary evaluation demonstrated potent activity against HRV-3 with low cytotoxicity. A docking analysis indicated that 8a could fit into, and form tight interactions (e.g., H-bonds, σ-π effect) with the active site in VP1.
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