Structure-activity relations on [1-(3,5-difluoro-4-hydroxyphenyl)-1H- pyrrol-3-yl]phenylmethanone. the effect of methoxy substitution on aldose reductase inhibitory activity and selectivity

DOI: 10.1016/j.bmc.2011.01.009

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Bioorganic and Medicinal Chemistry p. 1426 - 1433 (2011)

Update date:2022-09-26

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Authors:

Chatzopoulou, Maria

Mamadou, Eduard

Juskova, Maria

Koukoulitsa, Cathrine

Nicolaou, Ioannis

Stefek, Milan

Demopoulos, Vassilis J.

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Article abstract of DOI:10.1016/j.bmc.2011.01.009

Based on our previous work, we studied the effect of methoxy-substitution as well as the regioposition of the benzoyl-moiety of 4a [(1-(3,5-difluoro-4- hydroxyphenyl)-1H-pyrrol-3-yl)(phenyl)methanone]. On this basis, compounds 4b-c and 5a-c were synthesiz

Full text of DOI:10.1016/j.bmc.2011.01.009

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