Highly Stereocontrolled Synthesis of the Key Intermediate of 1β-Methylcarbapenem Antibiotic via Intramolecular Nitrone 1,3-Dipolar Cycloaddition

DOI: 10.1039/c39880000009

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 9 - 10 (1988)

Update date:2022-07-29

Topics:

Authors:

Ihara, Masataka

Takahashi, Masanobu

Fukumoto, Keiichiro

Kametani, Tetsuji

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1039/c39880000009

The key synthetic intermediate of 1β-methylcarbapenem antibiotic, (-)-(3S,4R)-3-<(1R)-1-t-butyldimethylsiloxyethyl>-4-<(2R)-2-(1-hydroxypropyl)>azetidin-2-one (2), was synthesized from (R)-methyl 3-hydroxy-2-methylpropionate with high stereoselectivity vi

Full text of DOI:10.1039/c39880000009

View Article Online / Journal Homepage / Table of Contents for this issue

View Article Online

Products guided by the article

Product name:C₁₅H₁₉NO₃

Cas No:127200-84-4

R&D Labs maybe for 127200-84-4

Tianjin Anda North Industrial & Business Co.Ltd.

Contact:86-22-24999306

Address:No.11 Erwei Road,Dongli Development Area,Tianjin,China
Ningbo J&S Botanics Inc.

Contact:86-574-26865651

Address:529 YuanBaoShan Road, Beilun District
HANGZHOU FOREWIN PHARMA CO., LTD

Contact:+86-571-89053961

Address:hangzhou
Weifang Adde Economic And Trade Co.,LTD.

Contact:86-536-8885548

Address:Room 1402,Wanda Plaza B Block,No.958,Yuanfei Road,Kuiwen District
Beijing Tianjia Chemical Science & Technology Co.,Ltd

Contact:86-0550-2392698

Address:No.388, Shiliang Road (East),

Relevant to this article

Protic ionic liquid [TMG][Ac] as an efficient, homogeneous and recyclable catalyst for one-pot four-component synthesis of 2H-indazolo[2,1-b]phthalazine- triones and dihydro-1H-pyrano[2,3-c]pyrazol-6-ones

Doi:10.1039/c4ra03514c
(2014)
Synthesis and antibacterial evaluation of a novel series of 2-(1,2-dihydro-3-oxo-3H-pyrazol-2-yl)benzothiazoles

Doi:10.1002/cbdv.201000241
(2011)
Self-assembly approach toward chiral bimetallic catalysts: Bis-urea-functionalized (Salen)cobalt complexes for the hydrolytic kinetic resolution of epoxides

Doi:10.1002/chem.201002600
(2011)
Synthesis and cytotoxicity of (-)-renieramycin G analogs

Doi:10.1016/j.bmcl.2011.01.025
(2011)
Synthesis and reactions of 2-amino-6-(3-methyl-5-oxo-1-phenyl-2-pyrazolin-4-yl)-4-phenylpyridine-3- carbonitrile

Doi:10.1002/jhet.5570390211
(2002)
Monoalkyl and monoanilide yttrium complexes containing tridentate pyridyl-1-azaallyl dianionic ligands

Doi:10.1039/c0dt01539c
(2011)

Article Doi