Highly Stereocontrolled Synthesis of the Key Intermediate of 1β-Methylcarbapenem Antibiotic via Intramolecular Nitrone 1,3-Dipolar Cycloaddition

DOI: 10.1039/c39880000009

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Journal of the Chemical Society. Chemical communications p. 9 - 10 (1988)

Update date:2022-07-29

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Authors:

Ihara, Masataka

Takahashi, Masanobu

Fukumoto, Keiichiro

Kametani, Tetsuji

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Article abstract of DOI:10.1039/c39880000009

The key synthetic intermediate of 1β-methylcarbapenem antibiotic, (-)-(3S,4R)-3-<(1R)-1-t-butyldimethylsiloxyethyl>-4-<(2R)-2-(1-hydroxypropyl)>azetidin-2-one (2), was synthesized from (R)-methyl 3-hydroxy-2-methylpropionate with high stereoselectivity vi

Full text of DOI:10.1039/c39880000009

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