Ruthenium-Catalyzed Chlorine Atom Transfer Cyclizations of N-Allylic α-Chloro-α-thioacetamides. Synthesis of (-)-Trachelanthamidine and Formal Total Synthesis of (+/-)-Haemanthidine and (+/-)-Pretazettine

Article abstract of DOI:10.1021/jo00061a005

A new method for the synthesis of five-membered lactams by ruthenium-catalyzed chlorine atom transfer cyclizations of N-allylic α-chloro-α-thioacetamides and the application of the method to the synthesis of the title alkaloids are described.A benzene sol