Manganese(III)-Based Oxidative Free-Radical Cyclization of Unsaturated β-Keto Esters, 1,3-Diketones, and Malonate Diesters

DOI: 10.1021/jo00295a035

Source and publish data:

Journal of Organic Chemistry p. 2427 - 2436 (1990)

Update date:2022-08-04

Topics:

Authors:

Kates, Steven A.

Dombroski, Mark A.

Snider, Barry B.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00295a035

Oxidative free-radical cyclizations of unsaturated β-keto esters, 1,3-diketones, and malonate diesters with 2 equiv of Mn(OAc)3*2H2O and 1 equiv of Cu(OAc)2*H2O are described.Oxidation of β-keto ester 1 with Mn(III) to enol radical 2 followed by 6-exo cyc

Full text of DOI:10.1021/jo00295a035

Products guided by the article

Product name:methyl 2-hydroxy-6-methyl-1,4-cyclohexadienecarboxylate

Cas No:127230-48-2

R&D Labs maybe for 127230-48-2

Beijing Mesochem Technology Co.,LTD

website:http://www.mesochem.com

Contact:0086-10-57862036

Address:2301, Floor 23, Building 9 Lippo Plaza, Yard 8 Ronghua Middle Road, ETDZ, Beijing, China
Taizhou Sunny Chemical Co.,Ltd

Contact:+86-523-86920899 +86-13951172783

Address:No.11 Xingyuang road, Gaoyong Chemical Industry Park, Gaogang Jiangsu China
Wuhan Silworld Chemical Co.,Ltd

website:http://www.silworldchemical.com

Contact:+86-27-85613400

Address:No.198 jiangjun Road, Wuhan,China 430033
Zhejiang Golden-Shell Pharmaceutical Co.,Ltd.

Contact:+86-576-87501888 / 87501988

Address:No.89 Zhongxing Road. Li'ao, Yuhuan, Zhejiang, China
Shanghai Rich Chemicals Co., Ltd

website:http://www.richchemical.com

Contact:+86-21-20255798

Address:Pudong Shanghai,China

Relevant to this article

Peptide-heterocycle chimera: New classes of more drug-like peptidomimetics by ligations of peptide-bis(electrophiles) with various bis(nucleophiles)

Doi:10.1002/ejoc.201001206
(2011)
Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses

Doi:10.1021/acs.jmedchem.6b01594
(2017)
New glucocerebrosidase inhibitors by exploration of chemical diversity of N -substituted aminocyclitols using click chemistry and in situ screening

Doi:10.1021/jm101204u
(2011)
Synthesis of chiral 1-substituted tetrahydroisoquinolines by the intramolecular 1,3-chirality transfer reaction catalyzed by Bi(OTf)₃

Doi:10.1021/jo102452d
(2011)
Ammonium oxalate as an efficient catalyst for one-pot synthesis of tetrahydrobenzo [a]xanthen-11-one derivatives under solvent-free conditions

Doi:10.1080/15533174.2012.754767
(2013)
Synthesis and thermal reactivity of 3-benzyl-7-trifluoromethyl-1H,3H- pyrrolo[1,2-c]thiazole-2,2-dioxide

Doi:10.1016/j.tet.2013.03.017
(2013)

Article Doi