Synthesis of methyl (E)-4-[2-(2,3-dihydro-3-methyl-3-hydroxymethyl-benzo[b]thien-5-yl)-1-propenyl]be nzoate [(E)-3], methyl (E)-4-[2-(2,3-dihydro-3-methyl-3-hydroxymethyl-5-benzofuranyl)-1-propenyl] benzoate [(E)-4], and methyl (E)-4-[2-(2,3-dihydro-3,3-dimethyl-5-benzofuranyl)-3-hydroxy-1-propenyl]benzoate [(E)-7] as potential metabolites of selected heteroarotinoids with fused five-membered ring

Full text of DOI:10.1080/00304940109356616

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Organic Preparations and Procedures
International: The New Journal for
Organic Synthesis
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SYNTHESIS OF METHYL (E)-4-
[2-(2,3-DIHYDRO-3-METHYL-3-
HYDROXYMETHYLBENZO[b]THIEN-5-
YL)-1-PROPENYL]BENZOATE [(E)-3],
METHYL (E)-4-[2-(2,3-DIHYDRO-3-
METHYL-3-HYDROXYMETHYL-5-
BENZOFURANYL)-1-PROPENYL]
BENZOATE [(E)-4], AND METHYL (E)-4-
[2-(2,3-DIHYDRO-3,3-DIMETHYL-5-
BENZOFURANYL)-3-HYDROXY-1-
PROPENYL]BENZOATE [(E)-7] AS
POTENTIAL METABOLITES OF SELECTED
HETEROAROTINOIDS WITH FUSED FIVE-
MEMBERED RINGS
Jonathan B. Gale a , Jozef Klucik a , Shankar Subramanian a & K.
Darrell Berlin a
a Department of Chemistry , Oklahoma State University , Stillwater,
OK, 74078
Published online: 18 Feb 2009.
To cite this article: Jonathan B. Gale , Jozef Klucik , Shankar Subramanian & K. Darrell Berlin (2001)
SYNTHESIS OF METHYL (E)-4-[2-(2,3-DIHYDRO-3-METHYL-3-HYDROXYMETHYLBENZO[b]THIEN-5-
YL)-1-PROPENYL]BENZOATE [(E)-3], METHYL (E)-4-[2-(2,3-DIHYDRO-3-METHYL-3-HYDROXYMETHYL-5-
BENZOFURANYL)-1-PROPENYL] BENZOATE [(E)-4], AND METHYL (E)-4-[2-(2,3-DIHYDRO-3,3-
DIMETHYL-5-BENZOFURANYL)-3-HYDROXY-1-PROPENYL]BENZOATE [(E)-7] AS POTENTIAL METABOLITES
OF SELECTED HETEROAROTINOIDS WITH FUSED FIVE-MEMBERED RINGS, Organic Preparations
and Procedures International: The New Journal for Organic Synthesis, 33:5, 487-499, DOI:
10.1080/00304940109356616

To link to this article: http://dx.doi.org/10.1080/00304940109356616
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