General Synthesis of β,γ-Alkynylglycine Derivatives

Article abstract of DOI:10.1021/jo00302a034

The coupling of α-haloglycinates 8 with alkynyltin reagents produces the fully protected β,γ-alkynylglycines 9.Subsequent deprotection of the amino or carboxyl groups generates differentially protected β,γ-alkynylglycine derivatives 10-14.The free amino a