Asymmetric synthesis of arylglycines

DOI: 10.1021/jo00299a009

Source and publish data:

Journal of Organic Chemistry p. 3723 - 3727 (1990)

Update date:2022-07-29

Topics:

Authors:

Williams

Hendrix Hendrix

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Article abstract of DOI:10.1021/jo00299a009

The asymmetric synthesis of several arylglycines are reported. The methodology deployed involves either cuprate or Friedel - Crafts couplings to chiral bromoglycinates. The % ee's range from 82 to 94%. Both an oxidative and reductive protocol are employed to unmask the oxazinone chiral auxilliary providing the free α-amino acids.

Full text of DOI:10.1021/jo00299a009

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