Synthesis and NMDA receptor binding of 2-amino-7,7-difluoro-7-phosphonoheptanoic acid

Article abstract of DOI:10.1016/S0040-4039(01)93411-2

In an NMDA specific receptor binding assay, 1 had lower affinity than its parent, APH. This result suggests that for competitive antagonists, diionization of the phosphonic acid moiety may be detrimental to receptor affinity.