Synthesis of spirocyclic compounds by a ring-expansion/cationic cyclization cascade reaction of chlorosulfate derivatives

Article abstract of DOI:10.1021/acs.orglett.0c01101

A novel cascade reaction to prepare spirocarbocyclic compounds from chlorosulfate derivatives has been developed. The process involves an unusual thermal elimination of the chlorosulfate moiety, a ring-expansion reaction, and a subsequent cationic cycliza