Antitumor agents. 113. New 4β-arylamino derivatives of 4'-O-demethylepipodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II

DOI: 10.1021/jm00171a050

Source and publish data:

Journal of Medicinal Chemistry p. 2660 - 2666 (1990)

Update date:2022-08-04

Topics:

Authors:

Wang Wang

Kuo Kuo

Schnur Schnur

Bowen Bowen

Liu Liu

Han Han

Chang Chang

Cheng Cheng

Lee Lee

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Article abstract of DOI:10.1021/jm00171a050

A number of 4'-O-demethylepipodophyllotoxin derivatives possessing various 4β-N-, 4β-O- or 4β-S-aromatic rings have been synthesized and evaluated for their inhibitory activity against the human DNA topoisomerase II as well as for their activity in causin

Full text of DOI:10.1021/jm00171a050

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