Antitumor agents. 113. New 4β-arylamino derivatives of 4'-O-demethylepipodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II

DOI: 10.1021/jm00171a050

Source and publish data:

Journal of Medicinal Chemistry p. 2660 - 2666 (1990)

Update date:2022-08-04

Topics:

Authors:

Wang Wang

Kuo Kuo

Schnur Schnur

Bowen Bowen

Liu Liu

Han Han

Chang Chang

Cheng Cheng

Lee Lee

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00171a050

A number of 4'-O-demethylepipodophyllotoxin derivatives possessing various 4β-N-, 4β-O- or 4β-S-aromatic rings have been synthesized and evaluated for their inhibitory activity against the human DNA topoisomerase II as well as for their activity in causin

Full text of DOI:10.1021/jm00171a050

Products guided by the article

Product name:Carbonic acid benzyl ester 4-[(5R,5aR,8aR,9S)-9-(4-fluoro-phenoxy)-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl]-2,6-dimethoxy-phenyl ester

Cas No:127882-52-4

R&D Labs maybe for 127882-52-4

HANGZHOU TOYOND BIOTECH CO., LTD

Contact:+86-571-86965177

Address:No. 189, Fengqi East Road, Hangzhou, China
Xinchang Jiu Xin Pharmaceutical Co., Ltd

website:http://www.jiuxinpharm.com

Contact:86 137 5756 8585

Address:Poyang industry Park
Puyang Huicheng Electronic Material Co., Ltd

website:http://huichengchem.weba.testwebsite.cn/index_en.html

Contact:+86-393-8910800

Address:West Section Shengli Road, Puyang457000, China
Anhui Redstar Pharmaceutical Corp., Ltd

Contact:+86-563-5120837

Address:Jingxian Industrial Development Zone, Anhui , China
ShangHai BMG Chemical Co., Ltd

Contact:+86-13524845543

Address:Room 602, no 291 sikai road shanghai

Relevant to this article

Ortho-(Dimesitylboryl)phenylphosphines: Positive boryl effect in the palladium-catalyzed suzuki-miyaura coupling of 2-chloropyridines

Doi:10.1002/adsc.201201100
(2013)
One-pot Preparation of Derivatives of the Unknown 1,9-Diazaphenalene Ring by a Consecutive Electrocyclic Ring-closure/Claisen Rearrangement/Intramolecular Amination Process

Doi:10.1039/c39900000007
(1990)
A facile preparation of 0-alkyl selenocarboxylates and selenoamides via Se-alkynyl selenocarboxylates¹())

Doi:10.1246/bcsj.63.835
(1990)
A [3 +2] Dipolar cycloaddition route to 3-hydroxy-3-alkyl oxindoles: An approach to pyrrolidinoindoline alkaloids

Doi:10.1021/ol200547m
(2011)
Addition Reactions and Rearrangements of 2,3-Bis(diphenylphosphino)propene and its Complexes with Group 6 Metal Carbonyls: Routes to Complexes of 1,2,3-Tris(diphenylphosphino)propane

Doi:10.1039/DT9900000489
(1990)
Doi:10.1246/cl.1972.1249
(1972)

Article Doi