Stereoselective synthesis of pipecolic acid derivatives using a aza-Diels-Alder reactions

DOI: 10.1016/S0040-4039(00)70675-7

Source and publish data:

Tetrahedron Letters p. 6781 - 6784 (1989)

Update date:2022-08-04

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Authors:

Bailey Bailey

Wilson Wilson

Brown Brown

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Article abstract of DOI:10.1016/S0040-4039(00)70675-7

Pipecolic acid derivatives can be prepared by the aza-Diels-Alder reaction of dienes with the iminium salt derived from benzylamine and ethyl glyoxylate in DMF; the presence of a catalytic quantity of water is essential, and acyclic dienes react with high regio- and diastereoselectivity.

Full text of DOI:10.1016/S0040-4039(00)70675-7

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