ALDOL REACTION OF IODODIFLUOROACETATE-Zn AND 2,2-DIFLUOROKETENE SILYL ACETAL

Article abstract of DOI:10.1016/S0040-4039(00)82048-1

Generation of the Reformatsky reagent of difluoroacetate from the iodide(2) and the difluoroketene silyl acetal(3), and their aldol reaction are described.High anti-selectivity with chiral aldehyde (5d, 5f) was found in the case of the ketene silyl acetal(3b). 2,2-Difluoro-2-deoxy analogs of D-ribo- and L-galactopyranosides (1a, 1b) were effectively prepared.