
Tetrahedron Letters p. 1803 - 1806 (1988)
Update date:2022-08-04
Topics:
Kitagawa, Osamu
Taguchi, Takeo
Kobayashi, Yoshiro
Generation of the Reformatsky reagent of difluoroacetate from the iodide(2) and the difluoroketene silyl acetal(3), and their aldol reaction are described.High anti-selectivity with chiral aldehyde (5d, 5f) was found in the case of the ketene silyl acetal(3b). 2,2-Difluoro-2-deoxy analogs of D-ribo- and L-galactopyranosides (1a, 1b) were effectively prepared.
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