Palladium-catalyzed arylation of the THP derivative of (Z)-2-butene-1,4- diol with arenediazonium salts and the synthesis of β-aryl-γ- butyrolactones

Article abstract of DOI:10.1055/s-0028-1087959

The reaction of arenediazonium tetrafluoroborates with the THP derivative of (Z)-2-butene-l,4-diol in the presence of Pd(OAc)₂ in MeOH at 35 °C gives 4-aryl-2-mefhoxytetrahydrofurans in good to high yields. The reaction tolerates a variety of u