Synthese et proprietes biologiques photoinduites de dioxinnocoumarines lineaires

Article abstract of DOI:10.1016/0223-5234(90)90163-W

Synthesis and photoinduced biological properties of linear dioxinocoumarins.Several dioxinocoumarins with a substituted or unsubstituted coumarin moiety were synthesized from commercially available 6-amino-1,4-benzodioxan.Qualitative assays on the photoinduced inhibition of growth in the yeast Saccharomyces cerevisiae indicate that two dioxinocoumarins are photobiologically active. The 5H-<2> benzopyrano<3,4-g><1,4>benzodioxin-5-one 1d is more active than angelicin but less active than 8-MOP.The 9-methyl-7H-pyrano<2,3-g><1,4>benzodioxin-7-one 1c is slightly less active than angelicin.