Synthesis of alkyl-substituted pyrroles by three-component coupling of carbonyl compound, amine and nitro-alkane/alkene on a solid surface of silica gel/alumina under microwave irradiation

Article abstract of DOI:10.1016/S0040-4020(01)00400-8

Efficient synthesis of highly substituted alkylpyrroles and fused pyrroles has been achieved by a three-component coupling of (a) α,β-unsaturated aldehyde/ketone, amine and nitroalkane and (b) α,β-unsaturated nitroalkene, aldehyde/ketone and amine on the surface of silica gel and alumina without any solvent under microwave irradiation.