SN2'Substitutions of 1,3-Dichloropropenes with the Functionalized Copper-Zinc Reagents RCu(CN)ZnX

DOI: 10.1016/S0040-4039(00)98797-5

Source and publish data:

Tetrahedron Letters p. 1829 - 1832 (1990)

Update date:2022-07-30

Topics:

Authors:

Chen, Huai Gu

Gage, Jennifer L.

Barrett, Stephen D.

Knochel, Paul

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)98797-5

The addition of benzenesulfenyl (or benzeneselenyl) chlorides to propargylic chlorides affords regio- and stereospecifically (E)-1,3-dichloro-2-phenylsulfenyl (or phenylselenyl) propenes (2a-c).These new reagents were found to react with excellent S_N2'selectivity with the highly functionalized copper-zinc reagents RCu(CN)ZnX, affording polyfunctional vinylic-thioethers or -selenides of type 3.The acidic hydrolysis of 3 furnishes symmetrical ketones in good yields.

Full text of DOI:10.1016/S0040-4039(00)98797-5

Products guided by the article

Product name:((E)-2-Chloro-1-chloromethyl-vinylsulfanyl)-benzene

Cas No:128538-19-2

R&D Labs maybe for 128538-19-2

Tianjin SPHINX SCIENTIFIC LAB.

Contact:+86-022-66211289

Address:Tianda high-tech Park. No.80,the 4th Avenue
Shandong Loyal Chemical industrial Co.,Ltd

Contact:0533-7451788

Address:Linzi Chemical Industrial Park, Zibo, Shandong Province
Jiangsu Chiatai Qingjiang Pharmaceutical Co.,Ltd

Contact:+86-517-86283327

Address:9 North Hantai Road, Huaian, China
JiYi Chemical (Beijing) Co., Ltd.

Contact:+86-10-89385733

Address:Shilou Town of Fangshan District， Beijing
Tangshan Wisdom Trading Co.,Ltd

Contact:86 315 2222979

Address:No.41 BeiXinXi Road, Yangguang building 1-1102 , Tangshan, Hebei, China

Relevant to this article

A phenanthrene based highly selective fluorogenic and visual sensor for Cu^{2 +} ion with nanomolar detection limit and its application in live cell imaging

Doi:10.1016/j.inoche.2012.08.012
(2012)
A novel and efficient synthetic method of benzo[f]chromen-1-ones and phenyl-4h-chromen-4-one through photooxidative cyclization of 6-[(E)-2-arylvinyl]-4H-pyran-4-ones and 6-[(1E,3E)-4-phenylbuta-1,3-dien-1-yl]-4H-pyran-4-one

Doi:10.1002/jhet.1694
(2014)
Alcohol dehydrogenase- and rat liver cytosol-dependent bioactivation of 1-chloro-2-hydroxy-3-butene to 1-chloro-3-buten-2-one, a bifunctional alkylating agent

Doi:10.1021/tx300369b
(2012)
Copper-catalyzed enantioselective allylic substitution with alkylboranes

Doi:10.1021/ja3093955
(2012)
Fluorescent stilbazolium dyes as probes of the norepinephrine transporter: Structural insights into substrate binding

Doi:10.1039/c2ob26633d
(2012)
Synthesis of pinacol arylboronates from aromatic amines: A metal-free transformation

Doi:10.1021/jo3018878
(2013)

Article Doi