5-Amino-4-trifluoromethylthiazoles and 5-Aminomethyl-4-trifluoromethyl-1,3-azoles: Useful Starting Materials for the Synthesis of Biologically Active Compounds

Article abstract of DOI:10.1055/s-1990-26878

The title compounds are obtained from 5-fluoro-4-trifluoromethyl-1,3-azoles.Introduction of various side chains of potential biological interest at C-5 can be achieved with electrophiles by reaction of the amino group.