Radical cyclization of ynamides into six- or eight-membered rings. Application to the synthesis of a protoberberine analog

Article abstract of DOI:10.1016/j.tetlet.2011.03.118

A straightforward formation of six- and eight-membered rings via the radical cyclization of specifically designed ynamides is reported. This strategy provides a protoberberine analog in only three steps by a radical cyclization cascade.