The Synthesis of 4(6)-t-Butylpyrimidines from 4(6)-Halopyrimidines by Using Higher-Order Lithium and Magnesium Organocuprate Reagents

Article abstract of DOI:10.1071/CH9900733

t-Butyllithium and t-butylmagnesium chloride cyanocuprates were used to prepare 4(6)-t-butylpyrimidines from the corresponding 4(6)-halopyrimidines.The highly hindered 2,4,5-tri-t-butyl-6-chloropyrimidine, containing an ortho-di-t-butyl arrangement, was p