Journal of Medicinal Chemistry p. 914 - 923 (2012)
Update date:2022-08-02
Topics:
Brown, Matthew F.
Reilly, Usa
Abramite, Joseph A.
Arcari, Joel T.
Oliver, Robert
Barham, Rose A.
Che, Ye
Chen, Jinshan Michael
Collantes, Elizabeth M.
Chung, Seung Won
Desbonnet, Charlene
Doty, Jonathan
Doroski, Matthew
Engtrakul, Juntyma J.
Harris, Thomas M.
Huband, Michael
Knafels, John D.
Leach, Karen L.
Liu, Shenping
Marfat, Anthony
Marra, Andrea
McElroy, Eric
Melnick, Michael
Menard, Carol A.
Montgomery, Justin I.
Mullins, Lisa
Noe, Mark. C.
O'Donnell, John
Penzien, Joseph
Plummer, Mark S.
Price, Loren M.
Shanmugasundaram, Veerabahu
Thoma, Christy
Uccello, Daniel P.
Warmus, Joseph S.
Wishka, Donn G.
In this paper, we present the synthesis and SAR as well as selectivity, pharmacokinetic, and infection model data for representative analogues of a novel series of potent antibacterial LpxC inhibitors represented by hydroxamic acid 1a.
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