Journal of Medicinal Chemistry p. 914 - 923 (2012)
Update date:2022-08-02
Topics:
Brown, Matthew F.
Reilly, Usa
Abramite, Joseph A.
Arcari, Joel T.
Oliver, Robert
Barham, Rose A.
Che, Ye
Chen, Jinshan Michael
Collantes, Elizabeth M.
Chung, Seung Won
Desbonnet, Charlene
Doty, Jonathan
Doroski, Matthew
Engtrakul, Juntyma J.
Harris, Thomas M.
Huband, Michael
Knafels, John D.
Leach, Karen L.
Liu, Shenping
Marfat, Anthony
Marra, Andrea
McElroy, Eric
Melnick, Michael
Menard, Carol A.
Montgomery, Justin I.
Mullins, Lisa
Noe, Mark. C.
O'Donnell, John
Penzien, Joseph
Plummer, Mark S.
Price, Loren M.
Shanmugasundaram, Veerabahu
Thoma, Christy
Uccello, Daniel P.
Warmus, Joseph S.
Wishka, Donn G.
In this paper, we present the synthesis and SAR as well as selectivity, pharmacokinetic, and infection model data for representative analogues of a novel series of potent antibacterial LpxC inhibitors represented by hydroxamic acid 1a.
View MoreZhejiang Genebest Pharmaceutical Co.,Ltd.
Contact:0086-571-63532866
Address:No.1 Jinboshi Rd Lishan Town Fuyang City Zhejiang Province China
Contact:0572-2722882
Address:1201,F3,xinghuibandao,
Wuhan Excellent Voyage Chemical Co.,Ltd
Contact:86-027-18771133548
Address:Joyful Avenue East Lake Tian Yu (Overseas Chinese town 1 phase) Hongshan District,Wuhan City, Hubei P.R.C China
Qingdao Pana-Life Biochem Co.,Ltd.
Contact:86-532-87683902
Address:No.967 Dalao Road, Licang Zone, Qingdao City,Shandong, China 266021
Neworld Chemical Co., Ltd Shanghai(expird)
Contact:+86-21-62202658
Address:11F, Blvd 2, No. 1969 PuXing Rd, Shanghai
Doi:10.1039/b923262a
(2010)Doi:10.1016/S0040-4039(01)93947-4
(1989)Doi:10.1039/C8NJ03360A
(2018)Doi:10.1016/j.tetasy.2010.12.003
(2011)Doi:10.1021/acs.jpcb.9b05688
(2019)Doi:10.1021/jacs.1c03772
(2021)