Bulletin of the Chemical Society of Japan p. 412 - 416 (1990)
Update date:2022-07-29
Topics:
Nishimura
Yasuda
Sasaki
Matsumoto
Kamimura
Sakane
Takaya
Two new 3-cyano-3-cephem derivatives, potassium 3-cyano-3-cephem-4-carboxylate (2) and potassium 7α-phenylacetamido-3-cyano-3-cephem-4-carboxylate (3), were prepared from 7β-aminocephalosporanic acid. Compounds 2 and 3 showed only weak β-lactamase inhibitory activity in contrast to sodium 7α-[(1R)-1-hydroxyethyl]-3-cyano-3-cephem-4-carboxylate (1), indicating the important role of the 7α-(1-hydroxyethyl) substituent for β-lactamase inhibitory activity.
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Doi:10.1016/j.tetlet.2011.01.057
(2011)Doi:10.1134/S1070428011020308
(2011)Doi:10.1039/c39900000843
(1990)Doi:10.1039/c39830000917
(1983)Doi:10.1016/j.tet.2011.02.017
(2011)Doi:10.1246/bcsj.63.1230
(1990)
