N-ISOPROPYL-N-METHYL FORMAMIDINE, A REAGENT FOR THE SYNTHESIS OF BIOACTIVE AMINO-ALCOHOLS

DOI: 10.1016/0040-4039(90)80097-6

Source and publish data:

Tetrahedron Letters p. 2157 - 2160 (1990)

Update date:2022-08-05

Topics:

Authors:

Solladie-Cavallo, A.

Bencheqroun, M.

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Article abstract of DOI:10.1016/0040-4039(90)80097-6

The lithium anion of N-isopropyl-N-methyl formamidine 1b reacts with aldehydes in yields up to 95percent leading to the less substituted addition-products, and thus provides a short synthesis (3 steps) of propanolol, an bioactive amino-alcohol.

Full text of DOI:10.1016/0040-4039(90)80097-6

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