Studies of the solid-phase Pauson-Khand reaction: Selective in-situ enone reduction to 3-azabicyclo[3.3.0] octanones

Article abstract of DOI:10.1016/S0040-4039(00)60352-0

The Smit-Caple DSAC Pauson-Khand cyclization of a series of N-protected allyl propargyl amines in the absence of oxygen gave rise to formation of the saturated azabicyclo[3.3.0]octanones in excellent yields. Standard cyclization in air gave mixtures of sa