Asymmetric synthesis of α-keto esters via Cu(II)-catalyzed aerobic deacylation of acetoacetate alkylation products: An unusually simple synthetic equivalent to the glyoxylate anion synthon

Article abstract of DOI:10.1021/ol200649u

Chemical equations presented. A simple and efficient method for the preparation of β-stereogenic α-keto esters is described using a copper(II)-catalyzed aerobic deacylation of substituted acetoacetate esters. The substrates for the title process arise fro