Design, Synthesis, and X-ray Crystallographic Analysis of Two Novel Spirolactam Systems as β-Turn Mimics

Article abstract of DOI:10.1021/jo00056a018

Two novel 5.4-spirolactam systems have been developed as β-turn mimics.The (R)-5.4-spirolactam system of 4 was designed to mimic the type-II β-turn, and the (S)-5.4-spirolactam system of 5 was designed to mimic the type-II' β-turn.The 5.4-spirolactam dipe