ACS Medicinal Chemistry Letters p. 461 - 465 (2011)
Update date:2022-07-29
Topics:
Hohlfeld, Konrad
Tomassi, Cyrille
Wegner, Joerg Kurt
Kesteleyn, Bart
Linclau, Bruno
A series of darunavir analogues featuring a substituted bis-THF ring as P2 ligand have been synthesized and evaluated. High affinity protease inhibitors (PIs) with an interesting activity on wild-type HIV and a panel of multi-PI resistant HIV-1 mutants co
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