DYNAMIC ASPECTS IN THE LDA LITHIATION OF AN ARABINOFURANOSYL DERIVATIVE OF 4-ETHOXY-2-PYRIMIDONE: REGIOSELECTIVE ENTRY TO BOTH C-5 AND C-6 SUBSTITUTIONS

DOI: 10.1016/S0040-4039(00)88789-4

Source and publish data:

Tetrahedron Letters p. 1295 - 1298 (1990)

Update date:2022-07-31

Topics:

Authors:

Shimizu, Miho

Tanaka, Hiromichi

Hayakawa, Hiroyuki

Miyasaka, Tadashi

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Article abstract of DOI:10.1016/S0040-4039(00)88789-4

Regioselectivity (C-5 vs.C-6) in the LDA lithiation of 1-<2,3,5-tris-O-(tert-butyldimethylsilyl)-β-D-arabinofuranosyl>-4-ethoxy-2-pyrimidone can be controlled simply by changing the reaction conditions, providing a route to both the 5- and 6-substituted d

Full text of DOI:10.1016/S0040-4039(00)88789-4

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