First Total Synthesis of (-)-Dioncophylline A ("Triphyophylline") and of the Selected Stereoisomers: Complete (Revised) Stereostrucure

Article abstract of DOI:10.1016/S0040-4039(00)94589-1

The first total synthesis of dioncophylline A (previously "triphyophylline") and some selected stereoisomers is described, using an intramolecular-type mixed aryl coupling method via ester-type prefixed molecular moieties.Simultaneously, this synthesis establishes the complete (revised) stereostructure of dioncophylline A as 1a, which is thereby the first fully elucidated naphthylisoquinoline alkaloid of Dioncophyllaceae.