STRUCTURE-ACTIVITY RELATIONSHIP OF NSTX-3, SPIDER TOXIN OF NEPHILA MACULATA

DOI: 10.1016/S0040-4020(01)90516-2

Source and publish data:

Tetrahedron p. 3813 - 3818 (1990)

Update date:2022-08-04

Topics:

Authors:

Teshima, Tadashi

Matsumoto, Takahiro

Wakamiya, Tateaki

Shiba, Tetsuo

Nakajima, Terumi

Kawai, Nobufumi

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Article abstract of DOI:10.1016/S0040-4020(01)90516-2

In a study on structure-activity relationship of spider toxin NSTX-3 obtained from venom of Nephila maculata, nine analogs or fragments of natural toxin were synthesized.Among them, des-Arg-NSTX-3 was found to be the minimum structure for blocking the excitatory transmission in the crustacean neuromuscular synapse.A positive charge of the arginine part was concluded to play the most important role for exhibition of the activity.

Full text of DOI:10.1016/S0040-4020(01)90516-2

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