Tetrahedron p. 3813 - 3818 (1990)
Update date:2022-08-04
Topics:
Teshima, Tadashi
Matsumoto, Takahiro
Wakamiya, Tateaki
Shiba, Tetsuo
Nakajima, Terumi
Kawai, Nobufumi
In a study on structure-activity relationship of spider toxin NSTX-3 obtained from venom of Nephila maculata, nine analogs or fragments of natural toxin were synthesized.Among them, des-Arg-NSTX-3 was found to be the minimum structure for blocking the excitatory transmission in the crustacean neuromuscular synapse.A positive charge of the arginine part was concluded to play the most important role for exhibition of the activity.
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Doi:10.1021/ol200659c
(2011)Doi:10.1021/jm101182s
(2011)Doi:10.1016/j.ejmech.2014.02.013
(2014)Doi:10.1016/j.tet.2011.02.064
(2011)Doi:10.1021/acs.joc.7b00697
(2017)Doi:10.1055/s-1990-26907
(1990)
