1,3-AMINOALCOHOLS BY REDUCTIVE CLEAVAGE OF ISOXAZOLIDINES WITH MOLYBDENUM HEXACARBONYL

DOI: 10.1016/S0040-4039(00)89062-0

Source and publish data:

Tetrahedron Letters p. 3351 - 3354 (1990)

Update date:2022-08-03

Topics:

Authors:

Cicchi, Stefano

Goti, Andrea

Brandi, Alberto

Guarna, Antonio

Sarlo, Francesco De

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Article abstract of DOI:10.1016/S0040-4039(00)89062-0

Isoxazolidines are reductively cleaved to 1,3-aminoalcohols by reacting with Mo(CO)6 and water.Reaction conditions are simple, mild and selective giving good yields of highly functionalized products with complete retention of configuration of the stereocenters.The reduction fails when steric hindrance is experienced by the nitrogen atom.

Full text of DOI:10.1016/S0040-4039(00)89062-0

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