Synthesis of (R)-4-oxo-5-phosphononorvaline, an N-methyl-D-aspartic acid receptor selective β-keto phosphonate

DOI: 10.1055/s-1994-25588

Source and publish data:

Synthesis p. 851 - 854 (1994)

Update date:2022-08-03

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Authors:

Rudisill

Whitten Whitten

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Article abstract of DOI:10.1055/s-1994-25588

(R)-4-Oxo-5-phosphononorvaline (1), a selective NMDA glutamate site antagonist, has been synthesized in four steps (overall yield = 31%) from (R)-aspartic acid, without racemization.

Full text of DOI:10.1055/s-1994-25588

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