Synthesis of (R)-4-oxo-5-phosphononorvaline, an N-methyl-D-aspartic acid receptor selective β-keto phosphonate

Article abstract of DOI:10.1055/s-1994-25588

(R)-4-Oxo-5-phosphononorvaline (1), a selective NMDA glutamate site antagonist, has been synthesized in four steps (overall yield = 31%) from (R)-aspartic acid, without racemization.